If the engine is running without surging in high vacuum or cruising conditions the jetting is adequate. If the power valve opens at 6.5" of Hg it will be open at WOT (or when you floor it). The amount of fuel contributed by the power valve is limited by the PVCR or power valve channel restriction, if the power valve is functioning correctly. A book like Holley Rebuilding & Modifying will explain how to tune this. Simply installing bigger jets will cause an over rich condition at cruise and destroy fuel economy. If your Holley has the correct metering block, the restrictions should be close. That leaves a bad power valve or a blockage.