I put an EFI 300 into my EB a few years ago and drove it for a couple of years. If you want to put the engine in, it'll go, but will be tight against the firewall and will extend the drivetrain by about 5". This will require driveshaft and transmission crossmember mods as well.
I made a number of other changes as well, although not because they were needed, but because I wanted things a certain way. In my case I put it into an EB frame that had the frame horns for a V-8 on it. I cut them off and dropped them down about 1.5", and notched the front crossmember as well. This allowed me to keep the CG lower than had I just put the engine in (which I could have done).
I did a bunch more stuff since I extended the wheelbase and cut off the inner fenders. You can see some pics here:
http://pages.prodigy.net/rjlougee/blue.html
If you've got some more specific questions I can help.
Joe