James has it. Vacuum hose through a grommet in that hole. If no more vacuum wipers, then no more hole. Definitely do your best to seal it off. Along with any other holes in the cowl area such as the "vent" holes that are often found at either end (or sometimes both ends) of the cowl facing the fender. Presumably there to allow moisture to evaporate, but in reality just a rust-creating water intrusion enhancer.
I say seal the cowl 100% from the outside and vent it to the cabin if you want to let air into the cavity.
That might have it's own set of issues, but I'm not sure what they are yet. Still working on it. If in doubt, make the vent holes in such a shape and size that you can use plugs to keep water out and then remove them when you want it to air out in the sun.
Paul