It's a '72 with the original harness. I've only had it a few months and stripped everything apart except for the wiring to do some body work and now putting it back together.
Did you make sure to replace (or make sure you had one in the first place) the grounding bond between the battery and body? This would have been part of the main cable on an original negative cable, or a separate "pigtail" on a new aftermarket replacement.
The main cable goes to the engine block obviously, but not so obvious sometimes is that the body needs it's own ground so all the rest of the stuff can work.
Now after 43 years, your body panels are not the most direct ground path anymore, so even adding more cables/wires/straps bonding the different sections of body together is not exactly a bad idea.
Being new-ish to vehicle electrics, you might not automatically have thought of this.
So for starters, just let us know if there is a ground wire from the battery negative to some part of the body, and we can go from there.
The fuse panel was all rusted out so I assumed some of my instrument panel problems were caused by the old fuse panel so I replaced it with a centech fuse box but no luck.
Rust is a common issue for our old fuse panels even if the truck was a CA vehicle all it's life.
But changing that out leaves lots of room for error. Good for you to have taken that large leap to get rid of the old stuff though.
Which Centech part did you use, and does it have separate busses for "always hot" and "switched hot" power circuits?
The ignition switch is new and I'm getting 12v from the ignition switch in the on position but no lights or instrument panel in "On".
Just to be sure, your large Black w/green stripe wire is still connected to the center stud of the ignition switch, correct? And just so you know for sure, this is NOT a ground wire. It's the main wire that feeds all the keyed accessories, including those protected by the fuse panel.
As you may know, the light circuits are not handled through the ignition switch. They're powered all the time directly from the battery through the large Black w/red stripe wire (can be just all Black for a '72 though) and the headlight switch.
Only the instrument lights are protected by the little tiny fuse (in the old panel) while all the main lights are protected by an auto-resetting circuit breaker built into the light switch itself.
If you don't have a good ground between the body and the battery, and the individual body panels and each other (spot welds are no longer a guaranteed connection after those 43 years), the ground electrons (not the proper terminology, but you get the point?) for the lights or other accessories might be hunting for a new path and finding that path through the ignition switch circuits somehow.
Might be a short-circuit in the wiring connections to the new fuse panel. Might be lack of grounding from the battery to the body, or it might be none of the above.
Got pics of under the hood? Got pics of under the dash too by any chance?
And speaking of that large Black wire... Your main power into the cab from the battery (while the engine is not running) is the large gauge Black wire attached to the starter relay/solenoid in the engine compartment. The main power source with the engine running is the alternator. Both use the same Black wire. DC electricity will flow in whichever direction the more powerful source is. So the battery's 12.5 or so volts powers everything until the alternator's 14.5 or so volts comes into play.
In the middle of this is a push/bullet connector just behind the ammeter gauge of the cluster. If this connection is weak, rusty or disconnected, you will have BIG problems. Usually nothing works at all if it's disconnected, so that's probably not your issue. But if it's rusty or loose enough, it could easily cause all sorts of trouble.
So you might as well check that connection right away. Should be a Black 10ga wire with a yellow stripe, just behind the dash on the left. Check it out and see what you see.
That's all I've got for now. Because you've done so much in the way of modifying your stock setup (new fuse panel mainly) you may need to dig deeper into what's been changed or what's not quite right. Like a bad solder joint or shorted connection, or missing ground, or whatever.
Good luck.
Paul