The EPA can have my rainwater when they pry it from my cold, wet hands.
Water Wetter is the easy way, but just about any water soluble oil will do the same thing. The idea is to add a surfactant that breaks the surface tension of water. Reduced surface tension makes it harder to form or retain air bubbles in the coolant jacket, which reduces or eliminates insulating air bubbles increasing the water to metal contact area.
Then there's the need for something that keeps the water pump seals alive, which water wetter is also supposed to do. I would absolutely use it in a water only, no coolant cooling system.
Not sure how effective it is when mixed into a water/coolant mixture. I'd expect that coolant would also be formulated to work as a surfactant and seal lube, but I've been disappointed before.