Hi Kbuck! You should still use the fender mounted "solenoid" or relay to power the solenoid on the starter.
See this wiring diagram:
http://www.supermotors.net/registry/media/870249
The fender solenoid provides a couple "convenient" features. It prevents starter run on, reduces the current flow through your ignition switch while cranking, provides full voltage (bypasses the resistor) to the coil while cranking, and provides a mounting terminal for all of the 12V wires - alternator charging wire, connection to the battery, starter power to the new starter, power to the cab, etc.
The MSD "ready to run" distributors are just a electronic version of a points distributor. It needs 12V positive for power. Very similar to a pertronix module in a points distributor. The MSD website shows the red wire goes to 12V (that should be "upstream" of the resistor, not the + post of the coil). Orange wire goes to the coil -. Black goes to a ground and grey to the tach, if you have one.
The coil + wire should have a resistor. Get the 12V for the distributor from the 12V side of the resistor. The lower voltage side of the resistor goes to the coil +. The resistor is needed unless you purchase a coil that specifically does not require the resistor. The MSD website does not say anything about the module adjusting the dwell time or being able to eliminate the resistor.
As far as wire routing, I run everything to the left side by the alternator and combine with the alternator wires, and then go along the passenger side of the engine bay.
Steve83 has some nice color coded wiring diagrams I've used for reference in the past. I'm sure Viperwolf will chime in too.