I'd think it easier to do whatever it takes with C bushings to get the drive-shaft optimized at normal ride height first. Measure the angle on the diff cover gasket surface and reproduce it out of the truck. Then cut the C's loose and set the Caster.
Not having done it myself, that's just my thought on how I'd approach the project.
This is going to be a little geeky. Don't read this if you are not tech saavy. (I'm using engineering language, and not mechanic language...)
You wouldn't actually do it this way. It is mostly correct conceptually...but you don't do it that way.
Because the OP has stated that he is not intending to move the wedges. If you do not have that degree of freedom...the driveshaft to pinion angle is constrained. If you are fully unconstrained...you can calculate (or empirically derive) the optimized pinion angle, then set the caster, then locate the wedges. BUT the wedges are not allowed to be a variable in the calculation. The wedge to pinion angle is fixed. So regardless of theoretical optimized pinion angle, you don't want to set the caster to an angle that your wedges don't correspond to.
Cutting off the wedges is a lot of work for zero benefit. Especially at 2.5 inches of lift. I postulate that if you liberate the wedges, establish the optimal pinion angle, and install the wedges with 0 degree bushings...they would go back to within a degree of where you cut them off. So don't. In practice, I establish the ride height. Then I "select" the C bushings that get me closest to desired pinion angle. Once I establish the "best fit" pinion angle...I use that to create caster. ( 2 degrees is trivial at the pinion...but critical at the knuckle.)
If you are narrowing a full width, then the wedges are already divorced from the tubes. In that scenario, you have full control of the wedge to pinion relationship. So you are not constrained to the 0, 2, 4, 7 degree C bushing increments... as
@widowmaker77 confirmed. But what he didn't mention is exactly how much he moved his wedges.
I hope that make sense...
James.